Mechanism of tonB-dependent transport of KP-736, a 1,5-dihydroxy-4-pyridone-substituted cephalosporin, into Escherichia coli K-12 cells.

Abstract

The mechanism of transport of KP-736, a novel cephalosporin with a 1,5-dihydroxy-4-pyridone moiety at the C-7 position, into the Escherichia coli K-12 cell was investigated by determining the susceptibilities of iron transport mutants to KP-736. The tonB mutant showed a higher degree of resistance to KP-736, indicating that KP-736 was incorporated into E… (More)

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@article{Tatsumi1995MechanismOT, title={Mechanism of tonB-dependent transport of KP-736, a 1,5-dihydroxy-4-pyridone-substituted cephalosporin, into Escherichia coli K-12 cells.}, author={Yoshiyuki Tatsumi and Takanori Maejima and Shoichi Mitsuhashi}, journal={Antimicrobial agents and chemotherapy}, year={1995}, volume={39 3}, pages={613-9} }