Mechanism of tissue factor activation on HL-60 cells.

@article{Bach1997MechanismOT,
  title={Mechanism of tissue factor activation on HL-60 cells.},
  author={Ronald R. Bach and Charles F. Moldow},
  journal={Blood},
  year={1997},
  volume={89 9},
  pages={
          3270-6
        }
}
Tissue factor (TF) procoagulant activity (PCA) on the surface of intact HL-60 cells is encrypted. This latent TF PCA was activated by exposing the cells to ionomycin, a calcium ionophore. Within seconds an increase in TF PCA of greater than 100-fold was observed. The ionomycin effect was blocked by pretreating the cells with calmidazolium, a calmodulin inhibitor. Changes in TF structure and function, coincident with the ionophore-induced increase in TF PCA, were identified. TF-factor VIIa… CONTINUE READING

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