Mechanism of thyroid hormone action.

@article{Harvey2002MechanismOT,
  title={Mechanism of thyroid hormone action.},
  author={Clare B. Harvey and Graham R. Williams},
  journal={Thyroid : official journal of the American Thyroid Association},
  year={2002},
  volume={12 6},
  pages={
          441-6
        }
}
  • C. Harvey, G. Williams
  • Published 2002
  • Biology, Medicine
  • Thyroid : official journal of the American Thyroid Association
Thyroid hormone (triiodothyronine [T3]) regulates gene expression by binding to high-affinity nuclear receptors. Thyroid hormone receptors (TRs) recognize specific response element sequences in the promoters of T3-target genes and activate or repress transcription in response to hormone. In this paper, we review the TR proteins and thyroid hormone response elements (TREs) to which they bind, the mechanisms of action of TRs bound to the TRE in basal and liganded conformations, and the… Expand
Thyroid hormone action at the cellular, genomic and target gene levels
TLDR
This review describes studies on TH action from the laboratory examining the cellular localization and motility of TRs using green fluorescent fusion proteins, gene expression profiles of TH in WT and TRalpha and TRbeta KO mice, as well as general transcription factor and co-activator recruitment on the promoters of target genes by TH in chromatin immunoprecipitation assays. Expand
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
Current information on the thyroid receptors studied in the vertebrate species are reviewed with emphasis on recent findings in goldfish concerning functional significance of the thyroid receptor subtypes. Expand
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