Mechanism of thioamide drug action against tuberculosis and leprosy

@article{Wang2007MechanismOT,
  title={Mechanism of thioamide drug action against tuberculosis and leprosy},
  author={Feng Wang and Robert W Langley and Gulcin Gulten and Lynn George Dover and Gurdyal S Besra and William Robert Jacobs and James C. Sacchettini},
  journal={The Journal of Experimental Medicine},
  year={2007},
  volume={204},
  pages={73 - 78}
}
Thioamide drugs, ethionamide (ETH) and prothionamide (PTH), are clinically effective in the treatment of Mycobacterium tuberculosis, M. leprae, and M. avium complex infections. Although generally considered second-line drugs for tuberculosis, their use has increased considerably as the number of multidrug resistant and extensively drug resistant tuberculosis cases continues to rise. Despite the widespread use of thioamide drugs to treat tuberculosis and leprosy, their precise mechanisms of… CONTINUE READING
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A clinical trial of ethionamide and on A ril 15

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