Mechanism of the vasodilator effect of mono-oxygenated xanthones: a structure-activity relationship study.

@article{Diniz2013MechanismOT,
  title={Mechanism of the vasodilator effect of mono-oxygenated xanthones: a structure-activity relationship study.},
  author={Thiago F. Diniz and Aline C Pereira and L. Capettini and M. H. Santos and T. Nagem and V. Lemos and S. C{\^o}rtes},
  journal={Planta medica},
  year={2013},
  volume={79 16},
  pages={
          1495-500
        }
}
  • Thiago F. Diniz, Aline C Pereira, +4 authors S. Côrtes
  • Published 2013
  • Chemistry, Medicine
  • Planta medica
  • The present study characterized the mechanisms involved in the vasodilator effect of two mono-oxygenated xanthones, 4-hydroxyxanthone and 4-methoxyxanthone. 9-Xanthenone, the base structure of xanthones, was used for comparison. 4-Hydroxyxanthone and 9-xanthenone induced a concentration-dependent and endothelium-independent vasodilator effect in arteries precontracted with phenylephrine (0.1 µmol · L-1) or KCl (50 mmol · L-1). 4-Methoxyxanthone induced a concentration-dependent vasodilator… CONTINUE READING
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