Mechanism of the tachycardia following systemic alpha-methyldopa administration in conscious rats.


The mechanism of the tachycardia observed in conscious rats following systemic administration of alpha-methyldopa (alpha-MD) was investigated. Heart rate and mean arterial pressure were monitored following peripheral (i.p. and i.v.) and central (lateral and fourth ventricle and cisterna magna) administration of alpha-MD. As little as 25 mg/kg i.p. produced… (More)


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