Mechanism of the radiosensitization induced by vinorelbine in human non-small cell lung cancer cells.

@article{Fukuoka2001MechanismOT,
  title={Mechanism of the radiosensitization induced by vinorelbine in human non-small cell lung cancer cells.},
  author={Kazuya Fukuoka and Hitoshi Arioka and Yasuo Iwamoto and Hisaoh Fukumoto and Hirokazu Kurokawa and Tomoyuki Ishida and Akira Tomonari and Toshihiro Suzuki and Jitsuo Usuda and Fumihiko Kanzawa and Nagahiro George Saijo and Kazuto Nishio},
  journal={Lung cancer},
  year={2001},
  volume={34 3},
  pages={451-60}
}
Vinorelbine (Navelbine, KW-2307), a semisynthetic vinca alkaloid, is a potent inhibitor of mitotic microtubule polymerization. The aims of this study were to demonstrate radiosensitization produced by vinorelbine in human non-small cell lung cancer (NSCLC) PC-9 cells and to elucidate the cellular mechanism of radiosensitization. A clonogenic assay demonstrated that PC-9 cells were sensitized to radiation by vinorelbine with a maximal sensitizer enhancement ratio at a 10% cell survival level of… CONTINUE READING
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