Mechanism of the natriuretic action of gamma-melanocyte-stimulating hormone.

@article{Chen1997MechanismOT,
  title={Mechanism of the natriuretic action of gamma-melanocyte-stimulating hormone.},
  author={Xiaojie Chen and W Z Ying and J. P. Valentin and King-Hwa Ling and Shun Y. Lin and Eckehart Wiedemann and Michael H. Humphreys},
  journal={The American journal of physiology},
  year={1997},
  volume={272 6 Pt 2},
  pages={R1946-53}
}
To explore the mechanism underlying the natriuretic effect of gamma-melanocyte-stimulating hormone (gamma-MSH), we infused the peptide intravenously at 200 pmol/min into anesthetized rats. gamma-MSH led to a progressive increase in urinary sodium excretion (UNaV), whereas continuous infusion of the vehicle did not affect UNaV. Plasma immunoreactive gamma-MSH was nine times greater at 120 min after the start of the infusion than in vehicle-infused rats. Plasma atrial natriuretic peptide (ANP… CONTINUE READING

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