Mechanism of the gBP21-mediated RNA/RNA annealing reaction: matchmaking and charge reduction.

@article{Mller2002MechanismOT,
  title={Mechanism of the gBP21-mediated RNA/RNA annealing reaction: matchmaking and charge reduction.},
  author={Ulrich F M{\"u}ller and H. Ulrich G{\"o}ringer},
  journal={Nucleic acids research},
  year={2002},
  volume={30 2},
  pages={447-55}
}
The guide RNA-binding protein gBP21 has been characterized as a mitochondrial RNA/RNA annealing factor. The protein co-immunoprecipitates with RNA editing ribonucleoprotein complexes, which suggests that gBP21 contributes its annealing activity to the RNA editing machinery. In support of this view, gBP21 was found to accelerate the hybridization of cognate guide (g)RNA/pre-edited mRNA pairs. Here we analyze the mechanism of the gBP21-mediated RNA annealing reaction. Three possible modes of… CONTINUE READING

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