Mechanism of the endothelium-dependent relaxation evoked by a grape seed extract.

@article{Edirisinghe2008MechanismOT,
  title={Mechanism of the endothelium-dependent relaxation evoked by a grape seed extract.},
  author={Indika Edirisinghe and Britt M Burton-Freeman and C Tissa Kappagoda},
  journal={Clinical science},
  year={2008},
  volume={114 4},
  pages={
          331-7
        }
}
GSEs (grape seed extracts) which contain polyphenolic compounds cause an endothelium-dependent relaxation of blood vessels. The aim of the present study was to examine the mechanisms involved in this response. A well-characterized GSE was applied to rabbit aortic rings suspended in organ baths containing Krebs-Henseleit buffer maintained at 37 degrees C. In aortic rings pre-contacted with noradrenaline (norepinephrine), the extract produced a dose-dependent relaxation. The maximum relaxations… 

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