Mechanism of the endothelium-dependent relaxation evoked by a grape seed extract.
@article{Edirisinghe2008MechanismOT, title={Mechanism of the endothelium-dependent relaxation evoked by a grape seed extract.}, author={Indika Edirisinghe and Britt M Burton-Freeman and C Tissa Kappagoda}, journal={Clinical science}, year={2008}, volume={114 4}, pages={ 331-7 } }
GSEs (grape seed extracts) which contain polyphenolic compounds cause an endothelium-dependent relaxation of blood vessels. The aim of the present study was to examine the mechanisms involved in this response. A well-characterized GSE was applied to rabbit aortic rings suspended in organ baths containing Krebs-Henseleit buffer maintained at 37 degrees C. In aortic rings pre-contacted with noradrenaline (norepinephrine), the extract produced a dose-dependent relaxation. The maximum relaxations…
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