Mechanism of the effect of varying PCO2 on gluconeogenesis from lactate in the perfused rat liver.

@article{Iles1978MechanismOT,
  title={Mechanism of the effect of varying PCO2 on gluconeogenesis from lactate in the perfused rat liver.},
  author={Richard A. Iles and ParametersR. Baron and Robert Donald Cohen},
  journal={Clinical science and molecular medicine},
  year={1978},
  volume={55 2},
  pages={
          183-8
        }
}
1. The effects of varying PCO2 on glucose output and the intracellular concentrations of lactate, pyruvate, phosphoenolpyruvate, 2-phosphoglycerate and 3-phosphoglycerate were studied in the isolated rat liver perfused with differing concentrations of lactate. 2. When the perfusate lactate concentration is above 1.5 mmol/l respiratory acidosis (simulated by high perfusate PCO2) inhibits gluconeogenesis from lactate, whereas respiratory alkalosis stimulates gluconeogenesis. 3. In general there… CONTINUE READING
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