Mechanism of the direct, negative inotropic effect of etomidate in isolated ferret ventricular myocardium.


BACKGROUND Etomidate exerts a mild, positive inotropic effect in rat ventricular myocardium, yet has a negative inotropic effect in isolated rabbit ventricular myocardium. The aim of this study was to investigate the mechanisms of etomidate's inotropic effect and its underlying mechanism in isolated ferret ventricular myocardium (which shows similar… (More)