Mechanism of the defect in gap-junctional communication by expression of a connexin 26 mutant associated with dominant deafness.

@article{Chen2005MechanismOT,
  title={Mechanism of the defect in gap-junctional communication by expression of a connexin 26 mutant associated with dominant deafness.},
  author={Yongyue Chen and Y Deng and Xiaozhong Bao and Luis Reuss and Guillermo A Altenberg},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={2005},
  volume={19 11},
  pages={1516-8}
}
Gap-junctional channels (connexin oligomers) are large-diameter aqueous pores formed by head-to-head association of two gap-junctional hemichannels, one from each of the adjacent cells. Profound hearing loss of genetic origin is common, and mutations of connexin 26 (Cx26) are the most frequent cause of this disorder. The Cx26 R75W mutant has been associated with disruption of cell-to-cell communication and profound hearing loss, but the mechanism of the gap-junctional defect is unknown. Here… CONTINUE READING
22 Citations
40 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 22 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 40 references

Molecular basis of calcium regulation in connexin-32 hemichannels

  • J. M. Gómez-Hernández, M. de Miguel, B. Larrosa, D. González, L. C. Barrio
  • Proc. Natl. Acad. Sci. USA
  • 2003

Similar Papers

Loading similar papers…