Mechanism of the dealkylation of tertiary amines by hepatic oxygenases. Stable isotope studies with 1-benzyl-4-cyano-4-phenylpiperidine.

@article{Mcmahon1979MechanismOT,
  title={Mechanism of the dealkylation of tertiary amines by hepatic oxygenases. Stable isotope studies with 1-benzyl-4-cyano-4-phenylpiperidine.},
  author={R. Mcmahon and H. W. Culp and J. C. Craig and N. Ekwuribe},
  journal={Journal of medicinal chemistry},
  year={1979},
  volume={22 9},
  pages={
          1100-3
        }
}
  • R. Mcmahon, H. W. Culp, +1 author N. Ekwuribe
  • Published 1979
  • Chemistry, Medicine
  • Journal of medicinal chemistry
  • The microsomal oxidative dealkylation of 1-benzyl-4-cyano-4-phenylpiperidine has been studied and the source of oxygen shown to be molecular oxygen. The rate of debenzylation was decreased by substituting deuterium for hydrogen in the methylene portion of the benzyl group. The isotope effect was measured by comparison of the reaction rates of the d0 and d2 compounds 1a and 1b and also of the d5 and d7 compounds 1c and 1d. Determination of the reaction rates for various mixtures of labeled and… CONTINUE READING
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