Mechanism of the congestion of lymph nodes induced by ellagic acid in rats

@article{Damas2005MechanismOT,
  title={Mechanism of the congestion of lymph nodes induced by ellagic acid in rats},
  author={Jacques Damas and G. Remacle-Volon and Albert Adam},
  journal={Agents and Actions},
  year={2005},
  volume={22},
  pages={202-208}
}
Intravenous injection of ellagic acid (EA, 30 mg/Kg), an activator of the Hageman factor, induced congestion of lymph nodes and dilatation of the spleen in rats. The dilatation of the spleen was inhibited by heparin, thrombin, defibrase, clocoumarol. lambda carrageenan, SBTI, PCR 4099 and CCI 17810. The congestion of lymph nodes was inhibited by heparin, thrombin, defibrase, clocoumarol, SBTI, lambda carrageenan, aspirin, indomethacin and ketoprofen, phentolamine and hexamethonium. Thrombin… Expand
Studies on the vascular and hematological changes induced by ellagic acid in rats
TLDR
It is concluded that the vascular changes induced by blood coagulation with ellagic acid resulted mainly from kinin formation. Expand

References

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Studies on the vascular and hematological changes induced by ellagic acid in rats
TLDR
It is concluded that the vascular changes induced by blood coagulation with ellagic acid resulted mainly from kinin formation. Expand
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TLDR
In immune platelet depleted rats, EA induced only the swelling of lymph nodes and of the spleen, and it is suggested that the pro-aggregating derivatives of arachidonic acid had a minor role in this stimulation. Expand
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TLDR
The chemical nature of the action of ellagic acid seemed to be related to the presence of o-dihydroxyl groups in its molecule, and appeared to activate Hageman factor in a manner analogous to that of glass surfaces. Expand
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