Mechanism of the carcinogenic action of benzene: irreversible binding to rat liver DNA.

@article{Lutz1977MechanismOT,
  title={Mechanism of the carcinogenic action of benzene: irreversible binding to rat liver DNA.},
  author={Wemer K. Lutz and Christian Schlatter},
  journal={Chemico-biological interactions},
  year={1977},
  volume={18 2},
  pages={241-5}
}
Introduction It has been established that exposure of animals and men to benzene (see Ref. 1 for a recent review on benzene toxicity) can result in darnage to the haematopoietic system and a relationship between such exposure and the development of leukemia is suggested by many case reports [2]. Since a common feature of chemical carcinogens is their interaction with biological macromolecules [ 3] , most probably a covalent binding of a reactive metabolite to DN A, and since the carcinogenicity… CONTINUE READING