Mechanism of the Susceptibility of Remodeled Pulmonary Vessels to Drug‐Induced Cell Killing

@inproceedings{Ibrahim2014MechanismOT,
  title={Mechanism of the Susceptibility of Remodeled Pulmonary Vessels to Drug‐Induced Cell Killing},
  author={Yasmine F. Ibrahim and Chi‐Ming Wong and Ludmila Pavlickova and Lingling Liu and Lobsang Trasar and Geetanjali Bansal and Yuichiro J Suzuki},
  booktitle={Journal of the American Heart Association},
  year={2014}
}
BACKGROUND Pulmonary arterial hypertension remains a devastating disease without a cure. The major complication of this disease is the abnormal growth of vascular cells, resulting in pulmonary vascular remodeling. Thus, agents, which affect the remodeled vessels by killing unwanted cells, should improve treatment strategies. The present study reports that antitumor drugs selectively kill vascular cells in remodeled pulmonary vessels in rat models of pulmonary hypertension. METHODS AND RESULTS… CONTINUE READING