Mechanism of the Sex Difference in Endothelial Dysfunction after Stroke

  title={Mechanism of the Sex Difference in Endothelial Dysfunction after Stroke},
  author={Catherine M. Davis and Stacy L. Fairbanks and Nabil J. Alkayed},
  journal={Translational Stroke Research},
Stroke, the number four cause of death in the USA, is a greatly debilitating event resulting from insufficient blood supply to the brain (cerebral ischemia). Endothelial dysfunction, primarily characterized by dampened endothelial-dependent vasodilation, is a major contributor to the development and outcome of stroke. This review discusses the role of soluble epoxide hydrolase, an enzyme responsible for the degradation of vasoprotective epoxyeicosatrienoic acids, in the context of the cerebral… CONTINUE READING


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