Mechanism of the ATP-dependent DNA end-resection machinery from Saccharomyces cerevisiae

  title={Mechanism of the ATP-dependent DNA end-resection machinery from Saccharomyces cerevisiae},
  author={Hengyao Niu and Woo-Hyun Chung and Zhu Zhu and Youngho Kwon and Weixing Zhao and Peter Chi and Rohit Prakash and Changhyun Seong and Dongqing Liu and Lucy Yang Lu and Grzegorz Ira and Patrick Sung},
If not properly processed and repaired, DNA double-strand breaks (DSBs) can give rise to deleterious chromosome rearrangements, which could ultimately lead to the tumour phenotype. DSB ends are resected in a 5′ to 3′ fashion in cells, to yield single-stranded DNA (ssDNA) for the recruitment of factors critical for DNA damage checkpoint activation and repair by homologous recombination. The resection process involves redundant pathways consisting of nucleases, DNA helicases and associated… CONTINUE READING
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mediators and helicases take on regulatory functions

  • P. Sung, Klein, H. Mechanism of homologous recombination
  • Nature Rev. Mol. Cell Biol. 7, 739–750
  • 2006

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