Mechanism of taxane neurotoxicity

@article{Hagiwara2004MechanismOT,
  title={Mechanism of taxane neurotoxicity},
  author={Hiroki Hagiwara and Yoshihide Sunada},
  journal={Breast Cancer},
  year={2004},
  volume={11},
  pages={82-85}
}
The two taxanes (paclitaxel and docetaxel) are widely employed in standard antineoplastic practice. Although these agents are now well established, some toxic side effects have been reported. Toxicity of these agents includes bone marrow suppression (principally neutropenia), hypersensitivity reactions, cutaneus reactions, edema and neurotoxicity. The most prominent neurotoxicity is a sensory neuropathy. Controlling neuropathy is crucial for maintaining the quality of life of patients because… 
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