Mechanism of synergy between N-phosphonacetyl-L-aspartate and dipyridamole in a human ovarian carcinoma cell line.

Abstract

Previous results from our laboratory have shown that the nucleoside transport inhibitor dipyridamole (DP) markedly augmented both the in vitro and in vivo activities of the pyrimidine antimetabolite N-phosphonacetyl-L-aspartate (PALA). In a human ovarian carcinoma cell line (2008), DP increased the activity of PALA by 1 to 2 logs in growth rate and… (More)

Topics

3 Figures and Tables

Cite this paper

@article{Chan1985MechanismOS, title={Mechanism of synergy between N-phosphonacetyl-L-aspartate and dipyridamole in a human ovarian carcinoma cell line.}, author={T. C. Chan and Stephen B. Howell}, journal={Cancer research}, year={1985}, volume={45 8}, pages={3598-604} }