Mechanism of synchronized Ca2+ oscillations in cortical neurons.

  title={Mechanism of synchronized Ca2+ oscillations in cortical neurons.},
  author={Xiuqiong Wang and E. I. Gruenstein},
  journal={Brain research},
  volume={767 2},
Dissociated rat cortical neurons reassociate in vitro to form synaptically connected networks. Removal of Mg2+ from the extracellular medium then induces neurons in the network to undergo synchronized oscillations of cytoplasmic calcium. Previous studies have shown that these calcium oscillations involve the activation of NMDA receptors and that the rising phase of each calcium spike is coincident with a brief burst of action potentials (Robinson et al., Jpn. J. Physiol. 43 (Suppl. 1) (1993… CONTINUE READING