Mechanism of suppressed renin-angiotensin system in spontaneously hypertensive rat (SHR).

@article{Watanabe1983MechanismOS,
  title={Mechanism of suppressed renin-angiotensin system in spontaneously hypertensive rat (SHR).},
  author={Masazumi Watanabe and Toru Nishikawa and Tomo Takagi and Yoichiro Kamiyama and Yoshifumi Tamura and A. Kumagai},
  journal={Clinical and experimental hypertension. Part A, Theory and practice},
  year={1983},
  volume={5 1},
  pages={49-70}
}
Plasma renin concentration (PRC) of SHR decreased with the elevation of blood pressure. In addition in vitro study of basal renin release from kidney slices obtained from SHR produced similar results. However kidney renin activity and total renin content in kidney of SHR were not less than those of Wistar rats. These results indicate that the decreased renin release from kidney might be responsible for the suppression of renin-angiotensin system of SHR after the development of hypertension… CONTINUE READING