Mechanism of statin-induced rhabdomyolysis.

@article{Sakamoto2013MechanismOS,
  title={Mechanism of statin-induced rhabdomyolysis.},
  author={K. Sakamoto and J. Kimura},
  journal={Journal of pharmacological sciences},
  year={2013},
  volume={123 4},
  pages={
          289-94
        }
}
Statins, a group of drugs used for the treatment of hypercholesterolemia, have adverse effects on skeletal muscle. The symptoms of these effects range from slight myalgia to severe rhabdomyolysis. The number of patients currently taking statins is estimated to be several millions worldwide. However, the mechanism of statins' myotoxic effects is unclear. Statins inhibit biosynthesis of mevalonate, a rate-limiting step of cholesterol synthesis, by inhibiting HMG-CoA reductase. Mevalonate is also… Expand
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