Mechanism of spontaneous excitability in human embryonic stem cell derived cardiomyocytes.

@article{Satin2004MechanismOS,
  title={Mechanism of spontaneous excitability in human embryonic stem cell derived cardiomyocytes.},
  author={Jonathan Satin and Izhak Kehat and Oren Caspi and Irit Huber and Gil Arbel and Ilanit Itzhaki and J{\'a}nos Magyar and Elizabeth A. Schroder and Ido Perlman and Lior Gepstein},
  journal={The Journal of physiology},
  year={2004},
  volume={559 Pt 2},
  pages={479-96}
}
Human embryonic stem cell-derived cardiomyocytes (hES-CMs) are thought to recapitulate the embryonic development of heart cells. Given the exciting potential of hES-CMs as replacement tissue in diseased hearts, we investigated the pharmacological sensitivity and ionic current of mid-stage hES-CMs (20-35 days post plating). A high-resolution microelectrode array was used to assess conduction in multicellular preparations of hES-CMs in spontaneously contracting embryoid bodies (EBs). TTX (10… CONTINUE READING