Mechanism of sodium channel block by local anesthetics, antiarrhythmics, and anticonvulsants

Abstract

Local anesthetics, antiarrhythmics, and anticonvulsants include both charged and electroneutral compounds that block voltage-gated sodium channels. Prior studies have revealed a common drug-binding region within the pore, but details about the binding sites and mechanism of block remain unclear. Here, we use the x-ray structure of a prokaryotic sodium… (More)
DOI: 10.1085/jgp.201611668

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