Mechanism of self-tolerance and events leading to autoimmune disease and autoantibody response.

  • Kenneth S Tung
  • Published 1994 in Clinical immunology and immunopathology


This review summarizes recent studies on the mechanisms of self-tolerance and autoimmune disease pathogenesis based primarily on the murine ovarian autoimmune disease models. The ovarian autoimmune disease was induced experimentally by three approaches: (1) transfer of normal T cells into syngeneic athymic nu/nu mice, (2) neonatal thymectomy, or (3… (More)


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