Mechanism of selective incorporation of the melanoma seeker 2-thiouracil into growing melanin.

@article{Napolitano1996MechanismOS,
  title={Mechanism of selective incorporation of the melanoma seeker 2-thiouracil into growing melanin.},
  author={Alessandra Napolitano and Anna Palumbo and Marco d'Ischia and Giuseppe Prota},
  journal={Journal of medicinal chemistry},
  year={1996},
  volume={39 26},
  pages={5192-201}
}
The mechanism of selective incorporation of 2-thiouracil (TU), a highly specific melanoma seeker, into growing melanins was investigated both in vitro and in vivo. Methods used included direct analysis of the melanins, by evaluation of the absorption at 350 nm (A350) and chemical degradation coupled with HPLC quantitation of pigment makers, i.e., pyrrole-2… CONTINUE READING