Mechanism of ritonavir changes in methadone pharmacokinetics and pharmacodynamics: I. Evidence against CYP3A mediation of methadone clearance.

@article{Kharasch2008MechanismOR,
  title={Mechanism of ritonavir changes in methadone pharmacokinetics and pharmacodynamics: I. Evidence against CYP3A mediation of methadone clearance.},
  author={Evan D. Kharasch and Pamela Sheffels Bedynek and S Park and Dale Whittington and Alysa A Walker and Christine J Hoffer},
  journal={Clinical pharmacology and therapeutics},
  year={2008},
  volume={84 4},
  pages={497-505}
}
Ritonavir diminishes methadone plasma concentrations, an effect attributed to CYP3A induction, but the actual mechanisms are unknown. We determined ritonavir effects on stereoselective methadone pharmacokinetics and clinical effects (pupillary miosis) in healthy human immunodeficiency virus-negative volunteers. Subjects received intravenous plus oral (deuterium-labeled) racemic methadone after no ritonavir, short-term (3-day) ritonavir, and steady-state ritonavir. Acute and steady-state… CONTINUE READING
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