Mechanism of ribosomal subunit joining during eukaryotic translation initiation.

@article{Acker2008MechanismOR,
  title={Mechanism of ribosomal subunit joining during eukaryotic translation initiation.},
  author={Michael G Acker and Jon R. Lorsch},
  journal={Biochemical Society transactions},
  year={2008},
  volume={36 Pt 4},
  pages={
          653-7
        }
}
Decades of research have yielded significant insight into the mechanism by which a cell translates an mRNA into the encoded protein. However many of the molecular details of the process remain a mystery. Translation initiation is an important control point in gene expression, and misregulation can lead to diseases such as cancer. A better understanding of the mechanism of translation initiation is imperative for the development of novel therapeutic agents. Recently, a combination of genetic… CONTINUE READING

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