Mechanism of riboflavine uptake by Caco-2 human intestinal epithelial cells.

@article{Said1994MechanismOR,
  title={Mechanism of riboflavine uptake by Caco-2 human intestinal epithelial cells.},
  author={Hamid M Said and Thomas Y Ma},
  journal={The American journal of physiology},
  year={1994},
  volume={266 1 Pt 1},
  pages={
          G15-21
        }
}
  • H. Said, T. Ma
  • Published 1994
  • Biology
  • The American journal of physiology
The cellular and molecular regulation of intestinal absorption of the water-soluble vitamin riboflavine (RF) is poorly understood. The availability of a suitable in vitro cultured system that possesses the transport characteristics of the native intestinal absorptive cells would provide a powerful means to address this issue. In this study, we examined RF uptake by the human-derived cultured Caco-2 intestinal epithelial cells. RF uptake was Na+ and pH independent and occurred without metabolic… 
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Riboflavin uptake in human trophoblast-derived BeWo cell monolayers: cellular translocation and regulatory mechanisms.
  • S. N. Huang, P. Swaan
  • Biology, Chemistry
    The Journal of pharmacology and experimental therapeutics
  • 2001
TLDR
The presence of high- affinity riboflavin transporter(s) on the microvillous membrane of BeWo cells that appears to be modulated by cellular cyclic nucleotide levels and calmodulin is reported.
Identification and Functional Expression of a Carrier-Mediated Riboflavin Transport System on Rabbit Corneal Epithelium
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Results suggest the presence of a specialized, high-affinity transport mechanism for riboflavin that is expressed on the apical side of rabbit corneal epithelium and may in turn be responsible for influx of rib oflavin from tears to cornea.
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