Mechanism of rhodium-catalyzed carbene formation from diazo compounds.

@article{Wong2007MechanismOR,
  title={Mechanism of rhodium-catalyzed carbene formation from diazo compounds.},
  author={Freeman M Wong and Jianbo Wang and Alvan C Hengge and Weiming Wu},
  journal={Organic letters},
  year={2007},
  volume={9 9},
  pages={1663-5}
}
[reaction: see text] A large and normal nitrogen-15 kinetic isotope effect of 1.035 +/- 0.003 provides direct support for the proposed mechanism for the rhodium-catalyzed carbene formation from diazo compounds, which involves the fast formation of a metal-diazo complex followed by rate-limiting extrusion of N2. The large magnitude of the KIE indicates… CONTINUE READING