Mechanism of resistance to benzalkonium chloride by Pseudomonas aeruginosa.

  title={Mechanism of resistance to benzalkonium chloride by Pseudomonas aeruginosa.},
  author={Yoshikazu Sakagami and Hirofumi Yokoyama and Hiroyuki Nishimura and Y Ose and Toshihiko Tashima},
  journal={Applied and environmental microbiology},
  volume={55 8},
The mechanisms of resistance of Pseudomonas aeruginosa to benzalkonium chloride (BC) were studied. The effluence of cell components was observed in susceptible P. aeruginosa by electron microscopy, but resistant P. aeruginosa seemed to be undamaged. No marked changes in cell surface potential between Escherichia coli NIHJC-2 and a spheroplast strain were found. The contents of phospholipids (PL) and fatty and neutral lipids (FNL) in the cell walls of resistant P. aeruginosa were higher than… CONTINUE READING