Mechanism of repression of RNA polymerase I transcription by the retinoblastoma protein.

@article{Voit1997MechanismOR,
  title={Mechanism of repression of RNA polymerase I transcription by the retinoblastoma protein.},
  author={Renate Voit and K Sch{\"a}fer and Ingrid Grummt},
  journal={Molecular and cellular biology},
  year={1997},
  volume={17 8},
  pages={4230-7}
}
The retinoblastoma susceptibility gene product pRb restricts cellular proliferation by affecting gene expression by all three classes of nuclear RNA polymerases. To elucidate the molecular mechanisms underlying pRb-mediated repression of ribosomal DNA (rDNA) transcription by RNA polymerase I, we have analyzed the effect of pRb in a reconstituted… CONTINUE READING