Mechanism of repolarization alternans has restitution of action potential duration dependent and independent components.

@article{Wu2006MechanismOR,
  title={Mechanism of repolarization alternans has restitution of action potential duration dependent and independent components.},
  author={Runze Wu and Abhijit Patwardhan},
  journal={Journal of cardiovascular electrophysiology},
  year={2006},
  volume={17 1},
  pages={87-93}
}
INTRODUCTION Investigation of relationship between diastolic-interval (DI)-dependent restitution of action potential duration (APD) and alternans of APD has produced conflicting results. We used a novel pacing protocol to determine the role of restitution in alternans by minimizing changes in DI preceding each activation. METHODS Transmembrane potentials were recorded from right ventricular endocardial tissue isolated from five dogs. We used three pacing sequences: (i) The tissue was paced at… CONTINUE READING
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