Mechanism of renal excretion of AM-715, a new quinolonecarboxylic acid derivative, in rabbits, dogs, and humans.

@article{Shimada1983MechanismOR,
  title={Mechanism of renal excretion of AM-715, a new quinolonecarboxylic acid derivative, in rabbits, dogs, and humans.},
  author={Jingoro Shimada and Tohru Yamaji and Yoshinori Ueda and Hisashi Uchida and Hisao Kusajima and Tsutomu Irikura},
  journal={Antimicrobial agents and chemotherapy},
  year={1983},
  volume={23 1},
  pages={
          1-7
        }
}
The mechanisms of the renal excretion of AM-715, a synthetic antimicrobial agent, were studied in rabbits, dogs, and humans. In both rabbits and humans, AM-715 clearance was greater than creatinine clearance and was profoundly decreased by the administration of probenecid. Thus, in these subjects, AM 715 was cleared by both tubular secretion and glomerular filtration. In dogs, however, the excretion ratio (close to unity), biological half-life, and stop-flow pattern of AM-715 were not affected… CONTINUE READING

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