Mechanism of regulation of the Epac family of cAMP-dependent RapGEFs.

Abstract

Epac1 (cAMP-GEFI) and Epac2 (cAMP-GEFII) are closely related guanine nucleotide exchange factors (GEFs) for the small GTPase Rap1, which are directly regulated by cAMP. Here we show that both GEFs efficiently activate Rap2 as well. A third member of the family, Repac (GFR), which lacks the cAMP dependent regulatory sequences, is a constitutive activator of… (More)

Topics

Cite this paper

@article{Rooij2000MechanismOR, title={Mechanism of regulation of the Epac family of cAMP-dependent RapGEFs.}, author={Johan de Rooij and Holger Rehmann and Miranda H van Triest and Richard Cool and Alfred Wittinghofer and J. L. Bos}, journal={The Journal of biological chemistry}, year={2000}, volume={275 27}, pages={20829-36} }