Mechanism of reduction in alveolar-arterial PO2 difference by helium breathing in the exercising horse.

@article{Erickson1994MechanismOR,
  title={Mechanism of reduction in alveolar-arterial PO2 difference by helium breathing in the exercising horse.},
  author={Bryan K Erickson and John Seaman and Keishi Kubo and Atsushi Hiraga and Mamiko Kai and Yoshiki Yamaya and Peter D. Wagner},
  journal={Journal of applied physiology},
  year={1994},
  volume={76 6},
  pages={2794-801}
}
Previous work has shown that replacing N2 in air with He at the same inspired O2 fraction reduces the exercise-induced alveolar-arterial PO2 difference (AaPO2) in horses but has provided no mechanism explaining this effect. We sought to distinguish among possible causes by using the multiple inert gas elimination technique. Six horses were studied on a high-speed treadmill while they breathed either ambient air or normoxic He-O2. O2 uptake reached 138.0 ml.min-1.kg-1 and was not affected by He… CONTINUE READING

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