Mechanism of recognition of the 5′ splice site in self-splicing group I introns

@article{Garriga1986MechanismOR,
  title={Mechanism of recognition of the 5′ splice site in self-splicing group I introns},
  author={Gian Garriga and Alan M. Lambowitz and Tan Inoue and Thomas R Cech},
  journal={Nature},
  year={1986},
  volume={322},
  pages={86-89}
}
Group I introns include many mitochondrial ribosomal RNA and messenger RNA introns and the nuclear rRNA introns of Tetrahymena and Physarum1–6. The splicing of precursor RNAs containing these introns is a two-step reaction. Cleavage at the 5′ splice site precedes cleavage at the 3′ splice site, the latter cleavage being coupled with exon ligation7–9… CONTINUE READING