Mechanism of pyrithione-induced membrane depolarization in Neurospora crassa.

Abstract

Pyrithione is a general inhibitor of membrane transport in fungi and is widely used in antidandruff shampoos as an antifungal agent. An electrophysiological approach has been used to determine the mode of action of pyrithione on the plasma membrane of the model ascomycete, Neurospora crassa. At pH 5.8, pyrithione induces a dramatic dose-dependent electrical… (More)

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