Mechanism of protective action of bicyclol against CCl-induced liver injury in mice.

@article{Liu2005MechanismOP,
  title={Mechanism of protective action of bicyclol against CCl-induced liver injury in mice.},
  author={Geng-tao Liu and Yan Li and Huai Ling Wei and Hui Zhang and Ji Yan Xu and Ling Yu},
  journal={Liver international : official journal of the International Association for the Study of the Liver},
  year={2005},
  volume={25 4},
  pages={872-9}
}
Bicyclol is a novel synthetic drug for the treatment of chronic viral hepatitis in China. This paper reports the protective action of bicyclol against experimental liver injury in mice and its mechanism of action. Oral administration of bicyclol markedly reduced the elevated serum transaminases (alanine aminotransferase (ALT) and aspartate aminotransferase (AST)) and the hepatic morphologic changes induced by CCl(4) in mice. Mechanistic studies demonstrated that bicyclol significantly inhibited… CONTINUE READING
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