Mechanism of prostaglandin E2-stimulated heat shock protein 27 induction in osteoblast-like MC3T3-E1 cells.

@article{Tokuda2002MechanismOP,
  title={Mechanism of prostaglandin E2-stimulated heat shock protein 27 induction in osteoblast-like MC3T3-E1 cells.},
  author={Haruhiko Tokuda and Osamu Kozawa and Masanao Niwa and Hiroyuki Matsuno and Kaori Kato and Toshihiko Uematsu},
  journal={The Journal of endocrinology},
  year={2002},
  volume={172 2},
  pages={
          271-81
        }
}
We investigated the effect of prostaglandin E2 (PGE2) on the induction of heat shock protein 27 (HSP27) and HSP70, and the mechanism behind the induction in osteoblast-like MC3T3-E1 cells. PGE2 time-dependently increased the level of HSP27 without affecting the level of HSP70. PGE2 stimulated the accumulation of HSP27 dose-dependently in the range between 10 nM and 10 microM. PGE2 stimulated the increase in the level of the mRNA for HSP27. Staurosporine and calphostin C, inhibitors of protein… CONTINUE READING

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Prostaglandins and bone metabolism

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