Mechanism of propranolol withdrawal phenomena.


Nine patients on chronic treatment with propranolol for essential hypertension for 3 months or longer were studied after abrupt discontinuation of the drug. Each patient demonstrated transient supersensitivity to the chronotropic effects of isoproterenol, beginning 2--6 days (median 4 days) after propranolol withdrawal, lasting for 3--13 days (median 6 days… (More)


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@article{Nattel1979MechanismOP, title={Mechanism of propranolol withdrawal phenomena.}, author={Stanley Nattel and Robert Rangno and Gunther van Loon}, journal={Circulation}, year={1979}, volume={59 6}, pages={1158-64} }