Mechanism of promoter activity of the beta-amyloid precursor protein gene in different cell lines: identification of a specific 30 bp fragment in the proximal promoter region.

Abstract

The amyloid beta-protein (Abeta) deposited in brains of Alzheimer's disease (AD) patients is proteolytically derived from a large Abeta precursor protein (APP). APP gene expression patterns in the AD brain region indicate that abnormalities of gene regulation may be important in AD pathology. To understand the contribution of different cell types to APP… (More)

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@article{Ge2004MechanismOP, title={Mechanism of promoter activity of the beta-amyloid precursor protein gene in different cell lines: identification of a specific 30 bp fragment in the proximal promoter region.}, author={Yuan-Wen Ge and Chandramallika Ghosh and Weihong Song and Bryan Maloney and Debomoy K. Lahiri}, journal={Journal of neurochemistry}, year={2004}, volume={90 6}, pages={1432-44} }