Mechanism of processing of the NF-κB2 p100 precursor: identification of the specific polyubiquitin chain-anchoring lysine residue and analysis of the role of NEDD8-modification on the SCFβ-TrCP ubiquitin ligase

@article{Amir2004MechanismOP,
  title={Mechanism of processing of the NF-κB2 p100 precursor: identification of the specific polyubiquitin chain-anchoring lysine residue and analysis of the role of NEDD8-modification on the SCFβ-TrCP ubiquitin ligase},
  author={Ruthie E Amir and Hans H{\"a}cker and Michael Karin and Aaron Ciechanover},
  journal={Oncogene},
  year={2004},
  volume={23},
  pages={2540-2547}
}
Processing of the NF-κB2 precursor p100 to the mature p52 subunit is regulated via a unique pathway. NF-κB-inducing kinase (NIK) induces IκB kinase α (IKKα)-mediated phosphorylation of specific serine residues in the C-terminal domain of p100, leading to recruitment of the SCFβ-TrCP ubiquitin ligase. We identified a single lysine residue, K855, that serves as the ubiquitin-anchoring residue required for signal-induced processing of p100. In a reconstituted system containing purified components… CONTINUE READING

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