Mechanism of potentiation of antithrombin III and heparin cofactor II inhibition by sulfated xylans.

@article{Carson1990MechanismOP,
  title={Mechanism of potentiation of antithrombin III and heparin cofactor II inhibition by sulfated xylans.},
  author={L. Carson and V. Doctor},
  journal={Thrombosis research},
  year={1990},
  volume={58 4},
  pages={
          367-81
        }
}
Kinetic analyses of antithrombin III (AT-III)-thrombin or heparin cofactor II (HC-II)-thrombin or AT-III-factor Xa interactions were carried out in the absence or in the presence of one of the sulfated xylans or unfractionated heparin or low molecular weight (LMW) heparin utilizing chromogenic substrates. These studies demonstrated that under pseudo first order conditions the inhibitions were proportional to the AT-III or HC-II concentrations used and the apparent second order rate constants… Expand
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TLDR
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