Mechanism of porphyrin-induced sonodynamic effect: possible role of hyperthermia.

  title={Mechanism of porphyrin-induced sonodynamic effect: possible role of hyperthermia.},
  author={Manabu Kinoshita and Kullervo Hynynen},
  journal={Radiation research},
  volume={165 3},
The biological effects of ultrasound have been investigated vigorously for various applications including the thermal coagulation of tissues, the opening of tight junctions, and localized gene or drug introduction. The synergistic cell killing effect of ultrasound and porphyrin derivatives, the so-called sonodynamic effect, holds promise for cancer treatment. Although several models to explain the sonodynamic effect have been proposed, its exact mechanism, especially in vivo, remains unknown… CONTINUE READING

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