Mechanism of pore formation in stearoyl-oleoyl-phosphatidylcholine membranes subjected to lateral tension

@article{Akimov2017MechanismOP,
  title={Mechanism of pore formation in stearoyl-oleoyl-phosphatidylcholine membranes subjected to lateral tension},
  author={Sergey A. Akimov and V. V. Aleksandrova and Timur R. Galimzyanov and Pavel V. Bashkirov and Oleg V Batishchev},
  journal={Biochemistry (Moscow), Supplement Series A: Membrane and Cell Biology},
  year={2017},
  volume={11},
  pages={193-205}
}
Theoretical model of a through pore formation in lipid bilayer membrane under applied lateral tension was developed. In the framework of elastic theory of liquid crystals adapted to lipid membranes, we calculated a continuous trajectory from intact bilayer through a hydrophobic defect to a through pore. It was shown that the major energetic characteristic of membrane stability with respect to the pore formation, i. e., line tension, depends both on the pore radius and on the value of the… CONTINUE READING