Mechanism of polymerase collision release from sliding clamps on the lagging strand.

@article{Georgescu2009MechanismOP,
  title={Mechanism of polymerase collision release from sliding clamps on the lagging strand.},
  author={Roxana E Georgescu and Isabel Kurth and Nina Y. Yao and Jelena A. Stewart and O. Y. Yurieva and Mike E O'Donnell},
  journal={The EMBO journal},
  year={2009},
  volume={28 19},
  pages={
          2981-91
        }
}
Replicative polymerases are tethered to DNA by sliding clamps for processive DNA synthesis. Despite attachment to a sliding clamp, the polymerase on the lagging strand must cycle on and off DNA for each Okazaki fragment. In the 'collision release' model, the lagging strand polymerase collides with the 5' terminus of an earlier completed fragment, which triggers it to release from DNA and from the clamp. This report examines the mechanism of collision release by the Escherichia coli Pol III… CONTINUE READING
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