Mechanism of photosignaling by Drosophila cryptochrome: role of the redox status of the flavin chromophore.

@article{Ozturk2014MechanismOP,
  title={Mechanism of photosignaling by Drosophila cryptochrome: role of the redox status of the flavin chromophore.},
  author={Nuri Ozturk and Christopher P. Selby and Dongping Zhong and Aziz Sancar},
  journal={The Journal of biological chemistry},
  year={2014},
  volume={289 8},
  pages={4634-42}
}
Cryptochrome (CRY) is the primary circadian photoreceptor in Drosophila. Upon light absorption, dCRY undergoes a conformational change that enables it to bind to Timeless (dTIM), as well as to two different E3 ligases that ubiquitylate dTIM and dCRY, respectively, resulting in their proteolysis and resetting the phase of the circadian rhythm. Purified dCRY contains oxidized flavin (FADox), which is readily photoreduced to the anionic semiquinone through a set of 3 highly conserved Trp residues… CONTINUE READING
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